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*INTRODUCTION Wheat grass can be traced back in history over 5000 years, to ancient Egypt and perhaps even  early Mesopotamian civilizations. It is purported that ancient Egyptians found sacred the young  leafy blades of wheat and prized them for their positive effect on their health and vitality. The  consumption of wheatgrass in the Western world began in the 1930s as a result of experiments  conducted by Charles F. Schnabel in his attempts to popularize the plant1. By 1940, cans of  Schnabel's powdered grass were on sale in major drug stores throughout the United States and  Canada [1] . Throughout human history, plants have played a key role in treating human diseases. In thousands of years of trials, human found many plants which are good for treating ailments and  curing serious health problems like cancer, diabetes, and atherosclerosis. They are a kind of alternative medicine that is inexpensive, and has no side effects. For example: whea...

phases of clinical research:- The  phases of clinical research  are the steps in which scientists do experiments with a  health intervention  in an attempt to find enough evidence for a process which would be useful as a  medical treatment . In the case of pharmaceutical study, the phases start with  drug design  and  drug discovery , go on to  animal testing , then start by testing in only a few  human subjects  and expand to test in many study participants if the trial seems safe and useful. Clinical trials involving new drugs are commonly classified into four phases. Clinical trials of drugs may not fit into a single phase. For example, some may blend from phase I to phase II or from phase II to phase III. Therefore, it may be easier to think of early phase studies and late phase studies. [1]  The drug-development process will normally proceed through all four phases over many years. If the drug successfully passes...

INTRODUCTION The gastric emptying of dosage forms is an extreme-ly variable process and ability to prolong and control the emptying time is a valuable asset for dosage forms that reside in the stomach for a longer period of time than conventional dosage forms. There are many difficulties faced in designing controlled release systems for better absorption and enhanced bioavailability. One of such difficulties is the inability to confine the dosage form in the desired area of the gastrointestinal tract. Drug absorption from the gastrointestinal tract is a complex procedure and is subject to many variables. It is widely acknowledged that the extent of ga-strointestinal tract drug absorption is related to contact time with the small intestinal mucosa (Hirtz, 1985). Thus, small intestinal transit time is an important parameter for drugs that are incompletely absorbed. Basic human physiology with the details of gastric emptying, motility patterns, and physio-logical and formulation varia...